Asda says it will no longer sell Nintendo's Wii U games console in its stores.
Customers wanting to buy the machine from the supermarket can still order it online and have it delivered to their homes or to a local store for pick-up.
Asda said rival consoles, Microsoft's Xbox 360 and Sony's PlayStation 3, would still be sold in-store.
This is despite the fact that the Wii U is the newest of the devices having only been launched in November.
"We continue to support Nintendo as a partner," Asda said in a statement.
It added that it had recently expanded the space allocated to sell Nintendo's 3DS XL and games for the handheld console.
The Wii U had been available in about 100 of Asda's 568 stores, but a spokesman denied the withdrawal was a sign of waning confidence in Nintendo.
In May, games giant EA said it had stopped developing new games for the Wii U, and Nintendo's company results revealed that sales targets for the console had fallen well below expectations.
Nintendo has blamed disappointing sales on the delayed release of key games, but says new titles, such as a 3D version of the long-running Super Mario series expected this Christmas, will help revive the Wii U's fortunes.